Autoinflammatory disorders (AID)


The autoinflammatory disorders are a group of diseases that, in their purest forms, manifest as recurrent fevers, high acute phase responses and a proclivity for inflammation of skin, joints, serosal surfaces and other organ involvement including the nervous system. These disorders lack the classical characteristics of autoimmune diseases such as high-titer autoantibodies. The innate immune system plays the primary pathophysiologic role in autoinflammatory diseases and in fact, these diseases are synonymous with dysregulation of the cells and molecular cascades intrinsic to innate immunity.

Reference centers

Center Country City    
Great Ormond Street / Royal Free Hospitals* UK London Adult unit Paediatric unit
The Leeds Teaching Hospitals NHS Trust* UK Leeds Adult unit
Barts Health NHS Trust* UK London Adult unit
Erasmus University Medical Center Netherlands Rotterdam Adult unit
UMC Groningen Netherlands Groningen Adult unit
Spedali Civili Brescia Italy Brescia   Paediatric unit
Pediatric Hospital Bambino Gesù, Rome Italy Rome   Paediatric unit
IRCCS Institute Giannina Gaslini Italy Genoa   Paediatric unit
UMC Utrecht Netherlands Utrecht   Paediatric unit
Foundation IRCCS Polyclinic San Matteo Italy Pavia Adult unit
Universitätsklinikum Münster Germany Münster Adult unit Paediatric unit
Assistance Publique-Hôpitaux de Paris, Hôpital Necker-Enfants Malades France Paris   Paediatric unit
Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre France Paris   Paediatric unit
Klinikum der Universität München Germany Munich Adult unit Paediatric unit
University Hospital Leuven Belgium Leuven Adult unit Paediatric unit
General University Hospital in Prague Czech Rep. Prague Adult unit Paediatric unit